Extraction of Pure Ketamine Powder and Study their Analgesic Effect as a Gel on Mice Using a Hot - Plate Test

Scientific Essay from the year 2012 in the subject Chemistry - Other, grade: 3, University of Mosul, course: Dental Chemistry, language: English, abstract: The present study was undertaken to extract ketamine powder from ketamine hydrochloride by precipitate ketamine. After that we examine the purity of this powder by infra-red (FTIR) and ultra-violet(UV) spectroscopy. ketamine gel in different concentrations was prepared ( 0.5 , 1 , 5 , 10 , 15 )% to evaluate the antinociceptive activity. ketamine powder was seen is pure and this show in infra-red and ultra-violet scanner. Ketamine gel at concentrations 0.5, 1, 5, 10,15) % produce antinociceptive in mice (5.6±2.2) (4.4±2.0) (8.2±4.3) (10.6±5.2) (8±2.1) second after 2 min respectively by using a hot plate test in comparison with control(2.4±2). The percentage of maximum possible effect (MPE) increased from (9.9) % in control group to (23.3) (18.3) (34.2) (44.2) (33.3)% respectively according to the concentrations of ketamine gel after 2 min . Purification of ketamine powder from ketamine solution and use as a gel to could be of value relief pain by topical application.

Amer A. Taqa: Professor at Dental Basic Science, College dentistry, Mosul University, Iraq. Have PhD degree in Dental chemistry. He has published more 100 researches papers in national and international academic journals and authored 22 books. His research interests include dental chemistry, medical chemistry, and inorganic chemistry. He is editorial member in more than 140 international journals. He Nominated as a member of the organizing committees for a number of international and local conferences. E-mail: amertaqa@hotmail.com Publons: https://publons.com/a/331136 ORCID: http://orcid.org/0000-0002-3104-0078