From Protein Structure to Function with Bioinformatics

309,23 €*

Nach dem Kauf zum Download bereit Ein Downloadlink ist wenige Minuten nach dem Kauf im eigenen Benutzerprofil verfügbar.

ISBN/EAN: 9789402410693

This book is about protein structural bioinformatics and how it can help understand and predict protein function. It covers structure-based methods that can assign and explain protein function based on overall folds, characteristics of protein surfaces, occurrence of small 3D motifs, protein-protein interactions and on dynamic properties. Such methods help extract maximum value from new experimental structures, but can often be applied to protein models. The book also, therefore, provides comprehensive coverage of methods for predicting or inferring protein structure, covering all structural classes from globular proteins and their membrane-resident counterparts to amyloid structures and intrinsically disordered proteins.

The book is split into two broad sections, the first covering methods to generate or infer protein structure, the second dealing with structure-based function annotation. Each chapter is written by world experts in the field. The first section covers methods ranging from traditional homology modelling and fold recognition to fragment-based ab initio methods, and includes a chapter, new for the second edition, on structure prediction using evolutionary covariance. Membrane proteins and intrinsically disordered proteins are each assigned chapters, while two new chapters deal with amyloid structures and means to predict modes of protein-protein interaction. The second section includes chapters covering functional diversity within protein folds and means to assign function based on surface properties and recurring motifs. Further chapters cover the key roles of protein dynamics in protein function and use of automated servers for function inference. The book concludes with two chapters covering case studies of structure prediction, based respectively on crystal structures and protein models, providing numerous examples of real-world usage of the methods mentioned previously.

This book is targeted at postgraduate students and academic researchers. It is most obviously of interest to protein bioinformaticians and structural biologists, but should also serve as a guide to biologists more broadly by highlighting the insights that structural bioinformatics can provide into proteins of their interest.



Daniel Rigden is a Reader in post-genomic bioinformatics in the Institute of Integrative Biology.  His interests span the broad relationships between protein sequences, structures and functions and how these evolve with time. As such, he applies a wide range of bioinformatics tools to diverse proteins of interest. This leads to interesting collaborations acorss the Institute and more broadly. A current prime interest is solution of crystal structures by Molecular Replacement using unconventional protein models, implemented in the program AMPLE.
Autor: Daniel J. Rigden
EAN: 9789402410693
eBook Format: PDF
Sprache: Englisch
Produktart: eBook
Veröffentlichungsdatum: 06.04.2017
Kategorie:
Schlagworte: Algorithms Bioinformatics Classification Databases Gene Ontology Secondary Structure

0 von 0 Bewertungen

Geben Sie eine Bewertung ab!

Teilen Sie Ihre Erfahrungen mit dem Produkt mit anderen Kunden.


shop display image

Möchten Sie lieber vor Ort einkaufen?

Haben Sie weiterführende Fragen zu diesem Buch oder anderen Produkten? Oder möchten Sie einfach doch lieber in der Buchhandlung stöbern? Wir sind gern persönlich für Sie da und beraten Sie auch telefonisch.

Buchhandlung Nettesheim GmbH
Hauptstraße 17
42349 Wuppertal
Telefon: 0202/472870

Mo – Fr09:30 – 18:00 UhrSa09:00 – 13:00 Uhr